NIKLAS KRAUSE Ph.D, M.P.H., M.D.

Selected references and abstracts


Lynch J; Krause N; Kaplan GA; Salonen R; Salonen JT. Workplace demands, economic reward, and progression of carotid atherosclerosis. Circulation 1997 Jul 1;96(1):302-7.

ABSTRACT:

BACKGROUND: Characteristics of the work environment have been associated with cardiovascular morbidity and mortality, but it is unclear whether these factors are associated with preclinical manifestations of disease.
METHODS AND RESULTS: We investigated the association between job demands, economic reward, and the 4-year progression of carotid atherosclerosis in a population-based sample of 940 Finnish men. Data from the Kuopio Ischemic Heart Disease Risk Factor Study were used to estimate changes in plaque height, maximum and mean intima-media thicknesses across combinations of job demands, and income. Associations were examined in relation to atherosclerotic risk factors and were stratified by baseline levels of atherosclerosis and prevalent ischemic heart disease. Men who had jobs with high demands and low economic rewards had significantly greater 4-year progression of plaque height (0.33 mm, P = .008) and maximum intima-media thickness (0.32, P = .03) than men with low-demand, high-income jobs. The magnitude of these differences was not greatly attenuated by risk factor adjustment and did not differ when examined by the level of workplace resources, social support, or employment status. Larger differences were observed in a subsample of men who had more advanced atherosclerosis at baseline.
CONCLUSIONS: These results show that men with demanding work that produces little economic reward have significantly greater progression of carotid atherosclerosis than more advantaged men. The relationship between job demands and health should be understood in a broad framework of interacting economic conditions, social circumstances, and behaviors that cascade over the life course and may ultimately contribute to socioeconomic inequalities in morbidity and mortality.


Lynch J; Krause N; Kaplan GA; Tuomilehto J; Salonen JT. Workplace conditions, socioeconomic status, and the risk of mortality and acute myocardial infarction: the Kuopio Ischemic Heart Disease Risk Factor Study. Am J Public Health 1997 Apr;87(4):617-22.

ABSTRACT:

OBJECTIVES: This study investigated whether the association between workplace conditions and the risk of all-cause and cardiovascular mortality and acute myocardial infarction differed by socioeconomic status.
METHODS: Prospective data were used to examine these associations in 2297 Finnish men, with adjustment for prevalent diseases and biological, behavioral, and psychosocial covariates, and stratified by employment status and workplace social support.
RESULTS: Elevated age-adjusted relative hazards for all-cause mortality were found for men who reported high demands, low resources, and low income; high demands, high resources, and low income; and low demands, high resources, and low income. Similar patterns were found for cardiovascular mortality. In contrast, elevated age-adjusted relative hazards for acute myocardial infarction were observed only in men who reported high demands, low resources, and low income. These results did not differ by level of workplace social support or employment status.
CONCLUSIONS: The negative effects of workplace conditions on mortality and of myocardial infarction risk depended on income level and were largely mediated by known risk factors.


Krause N; Ragland DR; Greiner BA; Syme SL; Fisher JM. Psychosocial job factors associated with back and neck pain in public transit operators. Scand J Work Environ Health 1997 Jun;23(3):179-86.

ABSTRACT:

OBJECTIVES: This cross-sectional study examined associations between psychosocial job factors and the prevalence of nondisabling back and neck pain in professional drivers after physical work load was taken into account.
METHODS: A total of 1449 transit vehicle operators completed a medical examination and a questionnaire yielding information on demographic and anthropometric variables, health status, and physical and psychosocial job factors. Company records were used to supplement information on employment history. Physical work load was measured in life-time years and current weekly hours of professional driving. The relation of psychosocial factors with back or neck pain was analyzed by logistic regression models adjusted for past and current physical work load, vehicle type, age, gender, body height, and weight.
RESULTS: The main result of this study was that both physical work load and psychosocial factors were simultaneously and independently associated with back or neck pain. Psychosocial factors associated with back or neck pain included extended uninterrupted driving driving periods, frequency of job problems, high psychosocial demands, high job dissatisfaction, and low supervisory support. An analysis of specific job problems is provided which may be useful in setting priorities for research and intervention efforts in this high risk occupation.
CONCLUSION: The results provide support for the role of psychosocial job characteristics in the etiology of back or neck pain in occupational settings.


Ragland DR; Greiner BA; Krause N; Holman BL; Fisher JM. Occupational and nonoccupational correlates of alcohol consumption in urban transit operators. Preventive Medicine, 1995 Nov, 24(6):634-45.

ABSTRACT:

BACKGROUND. The influence of occupation and the worksite has emerged as an important area of study in research on alcohol consumption. Occupational and nonoccupational factors were studied in relation to alcohol consumption using data from a 1983-1985 cross-sectional study of transit operators.
METHODS. A total of 1.853 operators underwent a medical examination for driver's license renewal (including information on age, ethnicity, gender, education). Of these operators, 1,448 completed a questionnaire about occupational (e.g., time of shift, job stressors) and nonoccupational (e.g., personality, life stressors) factors. From either the medical examination or the questionnaire, weekly alcohol consumption was available for 1,820 operators. Variables related to alcohol consumption in previous studies, or theoretically linked to consumption, were analyzed in relation to heavy ( > or = 15 drinks/week) and average weekly consumption.
RESULTS. Heavy and average consumption were both related to several nonoccupational variables, including demographic (age, ethnicity, gender, marital status), personality (depression, anger expression), and life stress variables (i.e., life events). Heavy and average consumption were also related to several occupational variables, including job history (number of years driving, specific worksite) and job stressors. Neither measure was related to subjective job content (job demand, decision latitude).
CONCLUSIONS. Variability in consumption by demographic factors among this population reflects that seen in society as a whole. However, occupational factors may influence consumption, since consumption was strongly related to (a) specific worksite and time of shift and (b) reported job stressors. Clarifying the exact influence of occupational and worksite factors on alcohol consumption will depend on the convergence of findings from different research designs (e.g., cross-sectional, longitudinal, ethnographic).


Krause N; Ragland DR. Occupational disability due to low back pain: a new interdisciplinary classification based on a phase model of disability. Spine 1994 May 1;19(9):1011-20.

ABSTRACT:

STUDY DESIGN. This study critically reviewed current conceptualizations of occupational disability resulting from low back pain (LBP). It proposes a new classification system for back pain built on a phase-model of disability.
OBJECTIVES. The goal was to develop a classification system that overcomes the shortcomings of existing classification schemes and is useful for interdisciplinary research, prevention, treatment, and rehabilitation.
SUMMARY OF BACKGROUND DATA. Attempts to study and prevent disability resulting from LBP have been hampered by the use of inadequate classifications of LBP.
METHODS. Current classifications of LBP were critically reviewed, and criteria for a useful classification system are described. The disabling process is organized in eight consecutive phases determined by the presence and duration of work disability.
RESULTS. The proposed eight-phase classification is based primarily on the presence and duration of work-disability rather than on clinical categories. It takes into account the developmental and social character of disability. The simplicity, reliability, and expandability of the model allow for its interdisciplinary use in research and intervention.
CONCLUSIONS. The prevention of disabling back pain requires an interdisciplinary approach. For this purpose, other than purely biomedical classifications of LBP are needed. The authors propose an eight-phase classification system primarily based on the duration of work disability and that takes into account other biomedical, developmental, and social characteristics of work-disability resulting from LBP.


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